
**This step is _optional_ and only applies to species standalone custom or advanced custom panel designs for [Xenium v1 panels](/support/software/xenium-panel-designer/latest/tutorials/pre-designed-xenium-v1)**. This step is **not** currently offered in the **Xenium Prime** panel design workflow - please submit requests in the Xenium Panel Designer and 10x support will work with you to finalize Xenium Prime advanced custom designs.

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This is the final, and optional, step of the [Request species standalone or advanced custom panels](/support/software/xenium-panel-designer/latest/tutorials/xenium-panel-design-workflow-guide#submit-request) workflow before submitting the request to a 10x bioinformatician.

To specify RNA-binding sequences for advanced custom probe sequences, create a CSV file formatted as specified in the [Species Standalone Custom and Advanced Custom Panel Design for Xenium In Situ Technical Note](/support/in-situ-gene-expression/documentation/steps/panel-design/species-standalone-custom-and-advanced-custom-panel-design-for-xenium-in-situ). This CSV file can be uploaded to the Xenium Panel Designer (see Provide Sequences step below) or you can work with your 10x bioinformatics representative to generate it.

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RNA-Binding Domains

Submitting RNA-binding sequences for Xenium v1 advanced custom designs in Xenium Panel Designer.

Specifying RNA-Binding Domains for Xenium v1 Panels

Advanced

10x Genomics Xenium Panel Designer is an app for designing custom panels.

Overview

Tutorials

FAQs

Release Notes

Datasets

Xenium Panel Designer

Introduction

Learn about pre-designed and custom panel design options to decide which is best-suited for your research.

Choose Design Option

Glossary of concepts important for understanding Xenium panel design.

Design Concepts and Terms

Walk through demonstrations of common Xenium Panel Designer use cases

Xenium Panel Designer Examples

Pre-designed Panels

Metadata for pre-designed Xenium v1 panels.

Xenium v1 Panel Info

Metadata for pre-designed Xenium Prime 5K panels.

Xenium Prime 5K Panel Info

Guidance for generating add-on, standalone custom, and advanced custom panel designs with the Xenium Panel Designer tool.

XPD Workflow Guide

Options for creating or selecting a single cell reference for custom panel design.

Create Single Cell Reference

Options for creating a gene list for custom panel design.

Create Gene List

Description of panel design summary HTML.

Interpret Xenium Panel Design Summary

Finalize Panel Design

Panel Part Numbers

Quick reference list for Xenium v1 pre-designed and custom panel part numbers.

Xenium v1 Panel PNs

Quick reference list for Xenium Prime 5K pre-designed and custom panel part numbers.

Xenium Prime 5K Panel PNs

Order a 10x Genomics pre-designed, off-the-shelf panel or design a custom panel with the Xenium Panel Designer app to perform Xenium In Situ Gene Expression analyses. Combine custom targets with pre-designed panels or build a standalone custom panel for maximum flexibility. Sign in to your existing 10x Cloud account or create a new account to get started today.

What is the Xenium Panel Designer?

Use the Xenium Panel Designer app to request custom panel designs. First, choose your custom panel design option. Then read the panel design request workflow guide to follow either the standard or advanced workflow.

Start Panel Request

Tell us about your panel request and enter a design ID if you have one.

Add Sample Info

Add on to a pre-designed panel or design a standalone custom panel. Select the panel type and number of targets.

Select Panel Type

Reference datasets are used to predict highly expressed genes that can cause optical crowding. For optimal results, use a dataset that closely aligns with your sample.

Provide Reference Datasets

Submit a list of custom genes to request for your custom panel design. Genes should be ranked in priority order from most to least important. In the standard workflow, the panel designer app will clean up the custom genes list and then generate a design for you to review.

Add Custom Genes

For advanced target or species standalone custom design requests, submit additional sequence information. This is not necessary for standard workflow design requests.

Advanced Workflow Step

Identify potential issues with your current panel and view the optimized panel design that incorporates all our recommendations.

Review Recommendations

If satisfied with the design, finalize to complete request. Please note that after designs are finalized, no further changes can be made to your panel design.

Review and Finish

Find answers to frequently asked questions about design ID, custom designs, and reference data.

We regularly add new features to the 10x Genomics Xenium Panel Designer. Find details about the updates and improvements on this page.

Access free, publicly available data generated with Xenium In Situ Gene Expression solutions.