Visium Spatial

Whole transcriptome discovery in the tissue context

10x Genomics Visium platform

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Introducing a new era of spatial discovery with Visium HD Spatial Gene Expression

  • Whole transcriptome analysis at single cell-scale resolution
  • Continuous tissue coverage
  • Best-in-class data powered by innovative probe-based chemistry and a Visium CytAssist-enabled workflow

Insights from spatial profiling in action

See how whole transcriptome spatial analysis has helped researchers identify cell types and cell–cell interactions that drive crucial functions in health and disease.

Assays

Flexible assays that suit your needs

Assay

HD Spatial Gene Expression

HD Spatial Gene Expression

Spatial Gene Expression v2 & v1

Spatial Gene Expression v2 & v1

Spatial Gene + Protein Expression

Spatial Gene + Protein Expression

What you can do

Proven whole transcriptome spatial analysis at single cell-scale resolution and continuous tissue coverage.

  • Whole transcriptome

Simultaneous analysis of molecular and imaging data from FFPE & frozen tissue sections.

  • Whole transcriptome

Simultaneous analysis of RNA and protein expression of FFPE tissues, using probe-based chemistry and tagged antibodies.

  • Whole transcriptome
  • Protein expression

Species compatibility

Human and mouse

Various

Human and mouse

Tissue compatibility

FFPE

FFPE

fresh frozen

fixed frozen

FFPE

Capture Area size

6.5 mm x 6.5mm

6.5 mm x 6.5 mm

11 mm x 11 mm

6.5 mm x 6.5 mm

11 mm x 11 mm

Analyte capture method

  • CytAssist enabled, probe-based chemistry (for FFPE)
  • CytAssist enabled, probe-based chemistry (for FFPE, fresh frozen, and fixed frozen)
  • Direct Placement, Probe-based chemistry (for FFPE)
  • CytAssist enabled, probe-based chemistry (for FFPE)
  • Visium CytAssist

    Simple sample handling and powerful spatial insights

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    1. Start with typical histology workflow on standard glass slides
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    3. Use the instrument to transfer slides to Visium capture areas
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    5. Proceed with the remaining Visium workflow
  • Visium CytAssist instrument
  • Analysis software

    An intuitive visual canvas for your spatial analysis

    Transform sequencing data into gene expression-aligned images

    Map the whole transcriptome across your tissue sections with Space Ranger, a set of analysis pipelines that process sequencing data with brightfield and fluorescence microscope images.

    Dive into your data and uncover new spatial biology insights

    Explore your Space Ranger results using Loupe Browser. Loupe Browser is a desktop application that enables you to easily navigate through molecular expression patterns overlaid on your original tissue section image.

    Resources

    Explore the power of spatial biology

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      Visium tumor data atlas

      Access Visium datasets of FFPE tumor samples and experience the power of spatially resolved biology.

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      Spatial datasets

      Access free, publicly available data from a number of different sample types generated with Visium spatial solutions.

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      Spatial publications

      Browse peer-reviewed publications and explore how researchers use 10x Genomics products to accelerate novel discoveries.

    Enhance your spatial discovery with complementary platforms

    Expand your Visium insights by interrogating single cell profiling with newly discovered mapped cell types or deepen your understanding of specific targets using Xenium subcellular precision.

    • 10x Genomics Chromium Single Cell Platform

      Perform transcriptomic profiling, with multiomic capabilities, in up to a million single cells

      Characterize tissue heterogeneity, discover rare cell types, and dissect molecular mechanisms cell by cell.

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      Target 100’s to 1000’s of RNAs in individual cells across a tissue sample

      Map gene expression at subcellular resolution with a diverse menu of validated, biologically relevant panels

    Start your Visium journey